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The U.S. Food and Drug Administration has approved the use of Contrave (naltrexone hydrochloride and bupropion hydrochloride extended-release tablets) to help you manage chronic obesity in adults with a body mass index (BMI) greater than 27, so long as they also have problems with weight-related health concerns such as Tupe2 diabestes, high cholesterol and/or hypertension (high blood pressure levels).Contrave is a combination of two FDA-approved drugs, naltrexone and bupropion, in an extended-release formulation. Naltrexone qualifies to treat alcohol and opioid dependence. Bupropion is approved to treat depression and seasonal affective disorder so that as an aid to stopping smoking treatment.'Obesity is still a major public health concern,' said Jean-Marc Guettier, M.D., director from the Division of Metabolism and Endocrinology Products in FDA's Center for Drug Evaluation and Research. 'When used as directed in combination which has a healthy lifestyle which includes a reduced-calorie diet and exercise, Contrave provides another treatment option for chronic weight-loss for people who are obese or are overweight and have at least one weight-related health problem.'The drug's effectiveness was evaluated in multiple numerous studies that included approximately 4,500 obese and overweight patients with and without significant weight-related conditions treated for one year. All patients received lifestyle modification that contained a reduced- calorie diet and regular physical exercise. Results from a medical trial that enrolled patients without diabetes established that patients had a normal weight loss of 4.1% instead of participants who have been given placebos) throughout a 12- month period, while an outside study involving patients with diabetes type 2 symptoms had the average weight loss of 2% over treatment with placebo at 12 months.
Using two separate drugs to shed pounds can be very effective there are combinations in front of the FDA now awaiting approval. When dealing with weight loss and the those who go through it you need to err on the side of caution and allow FDA do its job and demand some investigation be done so your public understands the side effects and perils associated with the medications before we take them. Keep in mind that drug companies are in business to earn money and that they would say anything to keep people on their own medications.
Researchers discovered that participants taking this drug for a year, lost weight within a month and have kept the extra weight off throughout the 56 weeks from the study. Contrave can be a combination in the drugs naltrexone and bupropion, which seems to reflect a new trend of weight-loss drugs which can be made up of multiple active ingredient, which can make them more efficient and safer.
Combo-pilling will be the newest fad or in addition to this the newest to come under scrutiny and for that reason it is just more publicly known although in the past, comb-pilling for losing weight has been around since the eighties. The biggest reason that utilizing a combination of pills has become popular may be the fact that since right now there are not any long term prescription diet pills that have been authorized by the FDA aside from orlistat. The truly disturbing part is always that doctors are prescribing these combinations of medications even though some of the combinations have been rejected or have yet to be licensed by the FDA.
Seizures really are a side effect with Contrave and must not be taken in people with seizure disorders. The drug can also raise blood pressure level and heartbeat, and shouldn't be used in those with a history of cardiac event or stroke in the last six months. Blood pressure and pulse should also be measured before starting the drug and throughout therapy using the drug.
The FDA also warned that Contrave can raise blood pressure and heartbeat and must not used in patients with uncontrolled high blood pressure, in addition to by a person with heart-related and cerebrovascular (blood vessel dysfunction impacting mental performance) disease. Patients using a history of heart attack or stroke in the last six months, life-threatening arrhythmias, or congestive heart failure were excluded from your clinical trials. Those taking Contrave needs to have their heart-rate and pulse monitored regularly. In addition, because the compound includes bupropion, Contrave comes with a boxed warning to alert physicians and patients for the increased probability of suicidal thoughts and behaviors related to antidepressant drugs. The warning also notes that serious neuropsychiatric events are actually reported in patients taking bupropion for smoking cessation.
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